کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1531962 | 1512019 | 2006 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Sustained-release of caffeine from a polymeric tablet matrix: An in vitro and pharmacokinetic study Sustained-release of caffeine from a polymeric tablet matrix: An in vitro and pharmacokinetic study](/preview/png/1531962.png)
Caffeine is utilized as a stimulant to impart a desired level of alertness during certain working hours. Usually, a single dose of caffeine induces 2–3 h of alertness coupled with side effects whereas a longer effect of 8–12 h is very useful for both daily life and military action. Thus, there is a need to deliver the stimulant continuously to an individual at one time to impart an increased level of alertness for the period stated after administration. This study aimed to design a polymeric microparticle system for sustained delivery of caffeine using a polymeric matrix. Poly(ethylene oxide) (PEO) was used as the erodible matrix material and the caffeine polymeric tablets were fabricated by compression using a Graseby Specac hydraulic press. In vitro release profiles as well as the pharmacokinetics studies data were obtained. Caffeine tablets fabricated using various polymers showed a high initial burst release type profile as compared to the caffeine-PEO-tablet. The PK studies showed sustained delivery of caffeine resulted in two expected phenomena: a reduction in the initial high rate of caffeine release (burst release) as well as a reduction in the change in caffeine concentration in the systemic circulation. A simple two-component system for sustained-release caffeine formulation therefore has been achieved.
Journal: Materials Science and Engineering: B - Volume 132, Issues 1–2, 25 July 2006, Pages 143–146