کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
155688 456909 2012 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lattice Boltzmann simulations of pinched flow fractionation
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Lattice Boltzmann simulations of pinched flow fractionation
چکیده انگلیسی

Direct numerical simulations of microsphere motion through a microfluidic separation device (pinched flow fractionation, PFF, device) were performed using the lattice Boltzmann method. The results were compared with the original experimental work on PFF by Yamada et al. (2004). The effects of the pinched segment width and the ratio between the particle solution and diluent flow rates were studied. Both analyses showed agreement with the experimental trends. Previous modelling of PFF has relied on the assumption that particles follow streamlines, and this assumption was evaluated. The simulations indicated that large particles experience a lift force due to a region of low pressure between the particle and the wall of the pinch. The lift force attracts the particles to the wall as they exit the pinched segment. Smaller particles experience a much weaker force. This force may provide an explanation for the experimental observation that a sharp expansion provides better separation performance than a gradual expansion, an effect that cannot be explained by streamline analyses.


► Microfluidic pinched flow fractionation was simulated.
► Computed particle trajectories were consistent with experimental work in the literature.
► Particles do not follow streamlines when they interact with walls.
► Deviation was caused by low pressure region between particle and wall.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemical Engineering Science - Volume 75, 18 June 2012, Pages 106–119
نویسندگان
, , ,