Modelling of the Corynebacterium glutamicum biosynthesis under aerobic fermentation conditions

This work concerns the modelling of the Corynebacterium glutamicum biosynthesis. At the beginning, the impulsive growth model of C. glutamicum under glutamate inhibition is established. According to this model, the analysis of the bioprocess stability is presented. Then, new objective functions are proposed and optimisation of C. glutamicum growth is presented. The results of the optimisation indicate that, although the growth of C. glutamicum is an aerobic process, the maximum of biomass productivity occurs under controlled penetration into the area of aerobic fermentation. Analytical results presented in this work are validated by numerical simulations.

► We examine the impulsive model of the Corynebacterium glutamicum biosynthesis.
► We analyse the bioprocess stability and present optimal growth conditions.
► Biomass growth depends on penetration into the area of aerobic fermentation.
► Aerobic fermentation should be kept at a low level to maximise C. glutamicum growth.