Advanced numerical method for generation of three-dimensional particles and its application in microstructure-based simulation of fatigue behavior

► A former step is proposed in the validation of microstructural tomographic approach. ► An advanced anisotropic mesh adaptation reconstructs 3D complex inclusions. ► The proposed approach allows a simple and fast immersion of the inclusions. ► Parallel computing highlights the potential to handle complex tomographic probe. ► A sensitivity analysis has been then carried out to optimize the REV.