کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
157323 456969 2009 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A particle-based model for the transport of erythrocytes in capillaries
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
A particle-based model for the transport of erythrocytes in capillaries
چکیده انگلیسی

This paper presents a two-dimensional (2D) particle-based model for the red blood cell, and uses it to compute cell deformation in simple shear and pressure-driven flows. The cell membrane is replaced by a set of discrete particles connected by nonlinear springs; the spring law enforces conservation of the membrane area to a high accuracy. In addition, a linear bending elasticity is implemented using the deviation of the local curvature from the innate curvature of the biconcave shape of a resting red blood cell. The cytoplasm and the external liquid are modeled as homogeneous Newtonian fluids, and discretized by particles as in standard smoothed particle hydrodynamics (SPH) solution of the Navier–Stokes equations. Thus, the discrete particles serve not only as a numerical device for solving the partial differential equations, but also as a means for incorporating microscopic physics into the model. Numerically, the fluid flow and membrane deformation are computed, via the particle motion, by a two-step explicit scheme. The model parameters are determined from experimental measurements of cell viscosity and elastic moduli for shear, areal dilatation and bending. In a simple shear flow, the cell typically deforms to an elongated shape, with the membrane and cytoplasm undergoing tank-treading motion. In a Poiseuille flow, the cell develops the characteristic parachute shape. These are consistent with the experimental observations. Comparison with prior computations using continuum models shows quantitative agreement without any fitting parameters, which is taken to be a validation of the particle-based model and the numerical algorithm.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemical Engineering Science - Volume 64, Issue 22, 16 November 2009, Pages 4488–4497
نویسندگان
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