pH influences intracellular reaction network of ββ-lactamase producing Bacillus licheniformis

Effects of pH on metabolic flux distributions in ββ-lactamase producing Bacillus licheniformis   were investigated using metabolic flux analysis, at pHC=6.5pHC=6.5, 7.0 and 7.5 controlled-pH conditions. The bioprocess was divided into three periods: Period I (0