کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1590711 1515442 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Study of acridine-DNA biopolymer interactions
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد دانش مواد (عمومی)
پیش نمایش صفحه اول مقاله
Study of acridine-DNA biopolymer interactions
چکیده انگلیسی
Acridine molecules elicit their mutagenicity and carcinogenicity through interaction with the basic genetic material, DNA. The biological activities of 9-amino-[N-(2-dimethylamino) ethyl] acridine-4-carboxamide are attributed to its effect on nucleic acid synthesis, which is accomplished by virtue of its ability to bind to DNA and interfere with functions of DNA. In view of this, stacking and in-plane intermolecular interactions between nucleic acid base pairs and of 9-amino-[N-(2-dimethylamino) ethyl] acridine-4-carboxamide drug have been evaluated using quantum mechanical methods. Binding patterns, relative stability of various drug-base pair complexes and preferred binding sites, etc. have been discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Crystal Growth and Characterization of Materials - Volume 52, Issues 1–2, March–June 2006, Pages 107-113
نویسندگان
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