Ion-implantation and characterization of 32P-radioactive platinum coils for endovascular treatment of intracranial aneurysms

We produced and measured over 800 32P-ion-implanted coils for pre-clinical and clinical studies. Platinum coils are intravascular implants most frequently used in the treatment of intracranial aneurysms. This less invasive endovascular approach is safer than conventional surgery, but a frequent drawback is the recurrence of the aneurysm, associated with recanalization, a phenomenon that can be inhibited by the local application of beta radiation. Total coil activities, uniformity, reproducibility and 32P binding to platinum were determined and found to be adequate for this application.