Biological fluid interaction with controlled surface properties of organic micro-fluidic devices

An organic micro-fluidic device (O-MFD) on silicon/glass substrate was fabricated using plasma polymerisation of acrylic acid (ppAc) with optical lithography including wet and dry etching techniques. The surface chemistry of O-MFD was controlled by depositing ppAc films on MFD. The results showed that these surfaces have more than 50% retention of original monomer functionalities (–COOX) with significant concentration of CO and C–OX at the surface. The water fluid velocity in 100 μm wide and 100 μm deep micro-channels of ppAc deposited O-MFD was increased by a factor of 10 relatively uncoated surfaces. The mixing of 10% of blood in the water has showed a decrease of about 100 μm/s in the fluid velocity relative to water and 10% red colour dye mixed water. The decrease in the fluid velocity of blood mixed water showed the possibility of blood cells interaction with the highly functional ppAc surfaces of micro-channel in O-MFD and that could have advantages in biological fluids (such as protein) separation.