Laccase-catalysed reaction between Meldrum's acid and catechols/hydroquinones – An investigation

Enzymatic oxidation of catechols/hydroquinones in the presence of Meldrum's acid as a nucleophile in aqueous solution has been investigated in detail by applying laccase as a catalyst. Optimization of the reaction through the use of HBT/ABTS/HPI as a mediator allowed a yield of more than 65% of the isolated product. We derived some new compounds with catechol/hydroquinone ring with moderate yields based on enzymatic synthesis in environmentally benign aqueous solution. These types of reactions represent a milestone along the path to future sustainable green chemistry.