کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
175857 458924 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The synthesis of new potential photosensitizers. Part 3. Tetraphenylporphyrin esters of profens
ترجمه فارسی عنوان
سنتز حساسیت های بالقوه جدید بالقوه. قسمت 3. استرافرونیلپورفیرین استرها
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
چکیده انگلیسی


• Six tetraphenyl derivatives of arylpropionic acids (profens) were synthesized.
• Basic physicochemical properties were determined.
• The compounds could be considered as potential PDT photosensitizers.

Six tetraphenyl derivatives of arylpropionic acids (profens) were synthesized in search for improved novel photosensitizers that might find application in photodynamic therapy (PDT) of various cancers. Our goal was to alter hydrophobic-hydrophylic characteristics of the tetraphenylporphyrin ring by substitution with propionyl derivatives. As starting materials we used profens known primarily from their widespread use as non-steroidal anti-inflammatory drugs (ibuprofen, naproxen, ketoprofen, fenoprofen, fluorbiprofen) and 2-phenylpropionic acid (model compound). The new compounds were characterized using spectroscopic and photophysical methods with focus given to measurement of molecules' lifetime in excited triplet state, time-resolved singlet oxygen phosphorescence and measurement of photostability. Fluorescence quantum yields were also determined; data revealed no planarity changes in the porphyrin molecule following substitution with profens.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Dyes and Pigments - Volume 116, May 2015, Pages 46–51
نویسندگان
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