Nonlinear characterization of breast cancer using multi-compression 3D ultrasound elastography in vivo

► We report a 3D elasticity imaging and visualization of breast masses in vitro and in vivo. ► Introducing a new mass classification method using material nonlinearity of breast masses. ► Estimating a tissue nonlinear parameter from multi-compression elastography. ► Enhancing breast mass boundary detection by utilizing different 3D strain imaging types.