کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
176688 458952 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, characterization and photodynamic activity of a new amphiphilic zinc phthalocyanine
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Synthesis, characterization and photodynamic activity of a new amphiphilic zinc phthalocyanine
چکیده انگلیسی

A new phthalonitrile derivative bearing hexyloxy groups in the 3,6- positions and p-sulfonylphenoxy- and chloro groups in the 4 and 5- positions was synthesized. The new hexadeca-substituted zinc phthalocyanine was obtained by cyclotetramerisation of this phthalonitrile derivative in the presence of anhydrous zinc acetate under microwave heating. The aggregation behavior of the amphiphilic zinc phthalocyanine was studied in methanol and water. All novel compounds have been characterized by using elemental analysis, UV–Vis, FT-IR, 1H NMR and MS spectroscopic data. The photosensitizing activity of this phthalocyanine dye was evaluated by application of 1,3-diphenylisobenzofuran as a singlet oxygen chemical quencher. In cell culture media the phthalocyanine showed a cytotoxic effect on HepG2 cells; a feature which encourages future in vivo studies.

Figure optionsDownload as PowerPoint slideHighlights
► An amphiphilic zinc phthalocyanine with three different substituents on each benzo moiety was synthesized.
► Hexadeca substitution of the phthalocyanine lowers the tendency for aggregation in water.
► The singlet oxygen generation capability of the phthalocyanine was studied.
►  In vitro photodynamic therapeutic activity of the phthalocyanine on HepG2 cells was studied.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Dyes and Pigments - Volume 97, Issue 1, April 2013, Pages 238–243
نویسندگان
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