Synthesis, antimicrobial activity and application of some novel quinazolinone based monoazo reactive dyes on various fibres

The main target of this paper was to synthesize novel reactive dyes that not only give good dyeing property but also show pharmacological activity i.e. antimicrobial activity (antibacterial and antifungal). In this regard ten novel monoazo quinazolinone based reactive dyes (7a–j) were made by coupling of diazotised 3-{4-[4-amino-2-nitrobenzyl]-3-nitrophenyl}-7-chloro-2-phenylquinazolin-4(3H)-one (4) with various p-chloro anilino cyanurated coupling components (6a–j). The structures of all these synthesized dyes were confirmed by elemental analysis and spectral methods. The antimicrobial activity, colorimetric data, solvent effect and fastness properties of these dyes were also investigated.

Research highlights
► We have synthesized ten new quinazolinone based reactive dyes by general process of diazotization and coupling.
► The newly synthesized reactive dyes were confirmed by various spectroscopic techniques like UV-vis, IR and NMR (1H, 13C).
► The synthesized dyes showed yellow to purple hues on silk, wool and cotton fibres with remarkable light, wash and rubbing fastness properties and also showed good antimicrobial activity.
► The colorimetric data showed that dye 7a showed highest color strength (K/S) value on silk, wool and cotton fibres.