Amperometric detection of Francisella tularensis genomic sequence on Zn-mediated diazonium modified substrates

• Potentiostat-free rapid and facile grafting of diazonium salts
• Enhanced genosensor performance
• Biowarfare agent detection

A simple, rapid and potentiostat-free method for grafting of close to monolayers of diazonium salts to anchor DNA probes for application in highly sensitive electrochemical genosensing is presented. Zn-mediated grafting is demonstrated to produce a highly organised surface facilitating enhanced sensitivity and a notably reduced detection limit as compared to electrochemical grafting.

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