Great application prospect in vivo: Efficient electroformation of giant vesicles on novel carbon fiber microelectrode

Microelectrode is firstly introduced into the research of vesicle formation. Carbon fibers are firstly applied as electrodes to construct vesicles by using electroformation method. Based on the superior electrode characteristics of carbon fiber, giant vesicles (GVs) of egg phosphatidylcholine (EggPC) were rapidly constructed after applying an AC electric field for 15-20 min. Study found that the carbon fiber is an excellent and efficient electrode for the electroformation of GVs. GVs are good drug carriers and represent the simple model systems of biological membranes. Due to the minisize of the carbon fiber electrode, GVs can be electroformed in the environment of a living body, which is expected to be in situ construction of artificial cell, drug delivery, and controlling release.

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► Carbon fibers are firstly applied as electrodes to construct vesicles.
► Vesicles were rapidly constructed after applying AC electric field for 15–20 min.
► Liberate the formation of vesicles from the restriction of conventional electrode