کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1798850 | 1524841 | 2015 | 7 صفحه PDF | دانلود رایگان |
The heating potential, cytotoxicity, and efficiency of Fe68.2Cr11.5Nb0.3B20 magnetic nanoparticles (MNPs), as such or coated with a chitosan layer, to decrease the cell viability in a cancer cell culture model by using high frequency alternating magnetic fields (AMF) have been studied. The specific absorption rate varied from 215 W/g for chitosan-free MNPs to about 190 W/g for chitosan-coated ones, and an equilibrium temperature of 46 °C was reached when chitosan-coated MNPs were subjected to AMF. The chitosan-free Fe68.2Cr11.5Nb0.3B20 MNPs proved a good biocompatibility and low cytotoxicity in all testing conditions, while the chitosan-coated ones induced strong tumoricidal effects when a cell–particle simultaneous co-incubation approach was used. In high frequency AMF, the particle-mediated heat treatment has proved to be a critical cause for decreasing in vitro the viability of a cancer cell line.
Journal: Journal of Magnetism and Magnetic Materials - Volume 380, 15 April 2015, Pages 13–19