کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1806091 | 1399657 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Assessment of a simplified spin and gradient echo (sSAGE) approach for human brain tumor perfusion imaging
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موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
فیزیک ماده چگال
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چکیده انگلیسی
The goal of this study was to validate a simplified spin- and gradient-echo (sSAGE) approach to obtain T1-corrected dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) data in a clinical brain tumor population. A five-echo SAGE sequence was used to acquire DSC-MRI data (n = 8 patients, 3 primary glioma, and 5 brain metastases). The ÎR2â and ÎR2 time series obtained from a nonlinear fit of all echoes (SAGE) were compared to ÎR2â and ÎR2 time series obtained analytically (sSAGE) using three echoes (two GEs and one SE). Through the use of multiple echoes, both methods removed T1 leakage effects from the ÎR2â and ÎR2 time series, and the sSAGE ÎR2â and ÎR2 time series were highly correlated with those from SAGE, with average correlations of 0.9. The resulting hemodynamic parameters included GE and SE cerebral blood volume (CBV), cerebral blood flow (CBF), mean vessel diameter (mVD), volume transfer constant (Ktrans), and volume fraction of the extravascular extracellular space (ve). For each metric, there was good correlation (>0.86) between sSAGE and SAGE, with no significant differences. The sSAGE method provides T1-corrected GE and SE DSC-MRI parameters in an efficient and clinically feasible manner.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Magnetic Resonance Imaging - Volume 34, Issue 9, November 2016, Pages 1248-1255
Journal: Magnetic Resonance Imaging - Volume 34, Issue 9, November 2016, Pages 1248-1255
نویسندگان
Ashley M. Stokes, Jack T. Skinner, Thomas Yankeelov, C. Chad Quarles,