کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1807303 1025253 2008 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MRI methodological development of intervertebral disc degeneration: a rabbit in vivo study at 9.4 T
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم فیزیک ماده چگال
پیش نمایش صفحه اول مقاله
MRI methodological development of intervertebral disc degeneration: a rabbit in vivo study at 9.4 T
چکیده انگلیسی

Intervertebral disc (IVD) degeneration is a complex process characterized by biochemical and structural changes in both the nucleus pulposus and the anulus fibrosus. In this study, we were able to obtain in vivo magnetic resonance (MR) images of the rabbit spine, with several MR imaging (MRI) contrasts (ρ, T1 and T2). We quantified several parameters (T2, apparent diffusion coefficient, disc height and area) to differentiate between healthy and degenerative IVDs and to characterize the degeneration process. To our knowledge, there has not been any previous in vivo study of rabbit IVDs at high-field MRI (9.4 T).A custom radio frequency (RF) coil for 9.4 T was designed to match rabbit IVD morphology, to study the degeneration in vivo on a model of human lumbar disease. Our new probe, a custom half-birdcage-type coil, obtains the necessary exploration depth while meeting the requirements for signal homogeneity and sensitivity of the study. This design addresses some of the difficulties with constructing RF coils at high field strengths.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Magnetic Resonance Imaging - Volume 26, Issue 10, December 2008, Pages 1421–1432
نویسندگان
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