کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1807532 | 1025265 | 2007 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
1H-MRS of the macaque monkey primary visual cortex at 7 T: strategies and pitfalls of shimming at the brain surface
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
فیزیک ماده چگال
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Magnetic resonance spectroscopy (MRS) is ideally suited for physiology-neurochemistry experiments with the living brain and particularly for studies on the primary visual cortex (striate cortex or area V1). Yet, the highly convoluted form of the human V1 has thus far prevented the performance of MRS investigations that are spatially confined within the gray matter of this area. Typically, these studies are compromised by partial volume contaminations originating from white matter tissue, cerebrospinal fluid and other cortical areas. In this study, was exploited the relative flatness of V1 in macaques to enable single-voxel 1H-MRS from a small volume (5Ã1.6Ã5 mm3, 40 μl) that was entirely confined within the V1 gray matter of anesthetized monkeys. Linewidths of 13.5±1.9 Hz and 13.0±1.3 Hz for water and creatine, respectively, were achieved with a two-step shimming strategy for voxels at the brain surface. The quality of the obtained results paves the way for further neuroscientific research, including studies on the cortical microcircuits and the dynamic longitudinal changes occurring during cortical reorganization and plasticity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Magnetic Resonance Imaging - Volume 25, Issue 6, July 2007, Pages 902-912
Journal: Magnetic Resonance Imaging - Volume 25, Issue 6, July 2007, Pages 902-912
نویسندگان
Christoph Juchem, Nikos K. Logothetis, Josef Pfeuffer,