A handy time alignment probe for timing calibration of PET scanners

Accurate time alignment of detectors in PET scanners is required for improving overall coincidence timing resolution. This is mandatory to reduce the coincidence time window of the scanner and limit as much as possible the rate of random events in images. Several techniques have been proposed so far, but most have shortcomings relating to difficult use, collection of huge amount of data or long acquisition times, not to mention transport regulation of radioactive source embedded in time alignment probes. A handy liquid scintillation beta probe was developed to overcome these problems. It consists of a PMT coupled to a small glass container that can be filled with a liquid scintillation cocktail loaded with radioactivity (such as 18F). The PMT signal is processed by an analog CFD and a digital TDC supplying an accurate timestamp on positron detection. When tested in coincidence with a fast PMT/plastic detector, a timing resolution of 1.1 ns FWHM was obtained using a standard off-the-shelf liquid cocktail having a scintillation decay time of 6.2 ns. For time alignment, coincidences are recorded between positron detected by the probe and one of the two 511 keV annihilation photons reaching detectors in the scanner. Using this simple probe, it is possible to determine the time offsets for individual LYSO and LGSO crystals in LabPET™ scanners in about 15 min. Due to its ease of use and short acquisition time, the proposed timing calibration method was found ideal for tuning the APD bias of individual detectors to reach optimal timing resolution on every channel.