کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1831276 | 1526499 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Investigation of the LabPET⢠detector and electronics for photon-counting CT imaging
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
ابزار دقیق
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The development of new molecular probes targeting receptors with high specificity in selected cells and tissues highlights the importance of obtaining the anatomical context in Positron Emission Tomography (PET) imaging. This can be achieved using another imaging modality, such as X-ray Computed Tomography (CT) or Magnetic Resonance Imaging (MRI), but the anatomic and molecular images obtained sequentially with different scanners must subsequently be co-registered and are subjected to motion artifacts. Conventional CT imaging also contributes a significant dose, which may compromise the benefits of longitudinal molecular imaging studies in the same subject. To overcome these difficulties, we have investigated the use of the LabPET⢠detector and electronics as a multi-modal detection system. Based on fast light emitting inorganic scintillators individually coupled to avalanche photodiodes and parallel, low-noise, fast digital processing electronics, the proposed detector front-end is suitable for coincidence detection of annihilation radiation (511 keV) in PET and for ultra-fast low-energy X-ray photon counting in CT. This combined detection system enables concurrent PET/CT imaging while potentially achieving superior image contrast sensitivity for a given dose in CT photon-counting mode. Anatomical images with millimeter spatial resolution and sufficient tissue contrast for anatomical localization in small animals have been obtained with doses in the mGy range. The CT performance for dual-modality imaging of small animals was analyzed in terms of spatial resolution, noise and image contrast sensitivity as a function of dose.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment - Volume 571, Issues 1â2, 1 February 2007, Pages 114-117
Journal: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment - Volume 571, Issues 1â2, 1 February 2007, Pages 114-117
نویسندگان
Philippe Bérard, Joel Riendeau, Catherine M. Pepin, Daniel Rouleau, Jules Cadorette, Réjean Fontaine, Roger Lecomte,