کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1832373 1027517 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Improved targeting of 5-[125I/131I]iodo-2′-deoxyuridine to rat hepatoma by using lipiodol emulsion
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم ابزار دقیق
پیش نمایش صفحه اول مقاله
Improved targeting of 5-[125I/131I]iodo-2′-deoxyuridine to rat hepatoma by using lipiodol emulsion
چکیده انگلیسی

This study aims to assess whether emulsion of [125/131I]IUdR and lipiodol (IUdR/LP) can improve delivery of IUdR into hepatoma.MethodsIn vitro release profile of IUdR from IUdR/LP to serum was performed. IUdR/LP was injected into N1-S1 hepatoma-bearing SD rat via hepatic artery and IUdR/normal saline (IUdR/NS) was used for comparison. Biodistribution, autoradiography, imaging and tumor DNA incorporation assay were performed. The radioactive metabolites in plasma and urine were analyzed. Radiation doses to tumor and organs were estimated.ResultsIUdR released from lipiodol into serum was fast. There were longer retention, more DNA incorporation and higher radiation dose of IUdR in the tumor by using IUdR/LP. IUdR/LP deposited deep in the hepatomas. Only free iodide was found in the plasma and urine after injection of IUdR/LP.ConclusionsHepatic artery injection of IUdR/LP emulsion could definitely enhance the tumor cell uptake and incorporation to DNA of *IUdR, prolong the tumor retention time and increase radiation dose to tumor. IUdR/LP may be an effective therapeutic agent for the treatment of hepatic tumors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment - Volume 569, Issue 2, 20 December 2006, Pages 538–542
نویسندگان
, , , , , , , , , , , , ,