کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1887701 | 1043604 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Funktionelle Hypoxie-Bildgebung mit FMISO PET zur Individualisierung der Strahlentherapie
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موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی پزشکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A dose painting strategy in order to overcome hypoxia-induced radiation resistance is presented. 15 HNC patients were examined with 18F-FDG and dynamic 18F-FMISO PET before the start of a 70 Gy radiotherapy. After approx. 20 Gy, a second dynamic 18F-FMISO scan was performed. The voxelbased 18F-FMISO PET data were analysed with a kinetic model, which allows for the determination of local tumour parameters for hypoxia and tissue perfusion. A statistical analysis showed, that only a combination of these two parameters predicted treatment outcome. A translation of the imaging data into a reliable dose prescription can only be reached via a TCP model that includes these functional parameters. The developed model was calibrated using the outcome data of the 15 HNC patients. This model allows to determine a map of locally varying dose escalation factors to be used for radiotherapy planning. A planning study showed that hypoxia dose painting is feasible without a higher burden for the organs at risk.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Zeitschrift für Medizinische Physik - Volume 18, Issue 1, 10 March 2008, Pages 43-50
Journal: Zeitschrift für Medizinische Physik - Volume 18, Issue 1, 10 March 2008, Pages 43-50
نویسندگان
Daniela Thorwarth, Markus Alber,