Dynamics of spiral waves in a cardiac electromechanical model with a local electrical inhomogeneity

Joint effect of electrical heterogeneity (e.g. induced by ischemia) and mechanical deformation is investigated for an anisotropic, quasi–incompressible model of cardiac electromechanical coupling (EMC) using the active strain approach and periodic boundary conditions. Three local inhomogeneities with different geometry are simulated. Under a specific stimulation protocol, the heterogeneities are able to induce spirals. The interplay between the dimension of the electrical inhomogeneity, the EMC and the mechano-electrical feedback provided by the stretch activated current (SAC) determines the dynamics of the spiral waves of excitation, which could extinguish (in the case of low SAC), or be stable (with the tip rotating inside the inhomogeneity), or drift and be annihilated (in the case of high SAC).

► I study spirals in a model of electromechanical coupling in a cardiac tissue.
► The model is anisotropic and includes an electrical heterogeneity.
► Mechanical deformation is described under the active strain hypothesis.
► Joint effect of inhomogeneity and deformation influences spiral dynamics.
► Conductivity of stretch activated current is the parameter most affecting spirals.