Resveratrol supplementation: Where are we now and where should we go?

• Resveratrol protects against angiogenesis, inflammation, and cancer.
• Resveratrol might have a wide spectrum of disease treatment applications.
• Dietary sources of resveratrol are not enough to have an impact on health.
• The effects of resveratrol are very much context dependent and tissue specific.
• New clinical trials are needed to firmly establish its therapeutic potential.

Pre-clinical findings have provided mounting evidence that resveratrol, a dietary polyphenol, may confer health benefits and protect against a variety of medical conditions and age-related complications. However, there is no consistent evidence of an increased protection against metabolic disorders and other ailments when comparing studies in laboratory animals and humans. A number of extraneous and potential confounding variables can affect the outcome of clinical research. To date, most of the studies that have investigated the effect of resveratrol administration on patient outcomes have been limited by their sample sizes. In this review, we will survey the latest advances regarding the timing, dosage, formulation, bioavailability, toxicity of resveratrol, and resveratrol–drug interactions in human studies. Moreover, the present report focuses on the actions of resveratrol treatment in combating diseases, such as cancer, diabetes, neurodegeneration, cardiovascular disease, and other age-related ailments.