کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1902234 1534313 2014 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
When astrocytes become harmful: Functional and inflammatory responses that contribute to Alzheimer's disease
ترجمه فارسی عنوان
هنگامی که آستروسیت ها مضر می شوند: پاسخ های عملکردی و التهابی که به بیماری آلزایمر کمک می کنند
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی


• Neuroinflammation is a constant feature in the AD brain and is an early phenomenon in AD development.
• Astrocytic activation is associated with changes in the expression of morphological hallmarks of Alzheimer's disease.
• Astrocytosis may be a bridge between amyloid deposition and cerebrovascular alterations.
• Astrocyte dysfunction triggers diverse biochemical pathways implicated in AD, such as calcium dysregulation and excitotoxicity.

A growing body of research suggests that astrocytes play roles as contributors to the pathophysiology of Alzheimer's disease (AD). Several lines of evidence propose that activated astrocytes produce and release proinflammatory molecules that may be critical for the generation of amyloid-β peptide (Aβ). However, accumulating evidence indicates that Aβ may activate astrocytes, which leads to an increase in cytokines that has been suggested to be a causative factor in the cognitive dysfunction of AD; thus, a vicious circle may be created. Intrinsic inflammatory mechanisms may provide a regulatory system that is capable of influencing the neuronal microenvironment that affects neuronal survival. In this article, we address the evidence surrounding the interactions of dysfunctional astrocytes with neighboring neurons that may initiate a cascade of events that culminates with neuronal injury and the expression of the hallmark lesions of AD. Comprehensive knowledge of the molecular mechanisms underlying the participation of astrocytes in neurodegeneration could aid the development of therapies to restore proper astrocyte function that can be used in AD patients to prevent or alleviate the progression of the disease in a more efficient and comprehensive manner.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ageing Research Reviews - Volume 18, November 2014, Pages 29–40
نویسندگان
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