کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1902267 1045731 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
From development to dysfunction: Microglia and the complement cascade in CNS homeostasis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
From development to dysfunction: Microglia and the complement cascade in CNS homeostasis
چکیده انگلیسی

Of the many mysteries that surround the brain, few surpass the awe-inspiring complexity of its development. The intricate wiring of the brain at both the system and molecular level is both spatially and temporally regulated in perfect synchrony. How such a delicate, yet elegant, system arises from an embryo's most basic cells remains at the forefront of neuroscientific research. At the cellular level, the competitive dance between synapses struggling to gain dominance seems to be refereed by both neurons themselves and microglia, the innate immune cells of the nervous system. Additionally, the unexpected complement cascade, a major effecter arm of the innate immune system, is almost certainly involved in synaptic remodeling by tagging destined neurons and synapses for destruction. As suddenly as they appear, the mechanisms of neurogenesis recede entering into adulthood. However, with age and insult, these mechanisms boisterously return, resulting in neurodegeneration. This review describes some of the mechanisms involved in synaptogenesis and wiring of the brain from the point of view of the innate immune system and then covers how similar molecular processes return with age and disease, specifically in the context of Alzheimer's disease.


► Contrary to earlier hypotheses, the developing brain is a complex milieu of innate and adaptive immune molecules and cells.
► The complement cascade is heavily involved in synaptic remodeling, especially the classical pathway via C1q and C3b.
► Microglia are the effecter cells that recognize complement components on predestined synapses to be eliminated.
► These same complement molecules and microglia can be reactivated during adulthood, resulting in neurodegeneration.
► Both microglia and complement are involved in the pathogenesis of Alzheimer's disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ageing Research Reviews - Volume 12, Issue 3, June 2013, Pages 749–756
نویسندگان
, ,