کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1902283 1045732 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulatory RNA-binding proteins in senescence
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Regulatory RNA-binding proteins in senescence
چکیده انگلیسی

The expression of senescence-associated genes, which governs the progression and the maintenance of senescence, is regulated at multiple levels. Apart from the transcriptional mechanisms that control cellular senescence, studies over the past decade have revealed that post-transcriptional gene regulation, especially through changes in mRNA turnover and translation, critically influences protein expression patterns in the senescent cell. Among the post-transcriptional regulatory factors, RNA-binding proteins (RBPs) are particularly influential in the establishment of senescence-associated protein profiles. In this review, I discuss the current knowledge of the role of RBPs in cellular senescence and the molecular mechanisms that regulate their function.


► RBPs-mediated posttranscriptional regulation is important for the process of cellular senescence.
► The turnover or translation efficiency of an individual mRNA encoding a key regulatory factor of cellular senescence may be regulated by multiple RBPs.
► Interaction between different RBPs determines the fate of mRNAs (e.g., turnover, translation).
► Protein phosphorylation is an universal modification for RBPs involving in cellular senescence.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ageing Research Reviews - Volume 11, Issue 4, September 2012, Pages 485–490
نویسندگان
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