Immunological hurdles of ageing: Indispensable research of the human model

► Ageing of the population is a global pandemic that impose biomedical and socioeconomic challenges. ► A national priority supporting Human Ageing Research is key to improving quality of life of elders. ► The immunologic milieu of elders is substantially different from young adults and children. ► Innovations in immune interventions for the elderly will have to be age-specific.