کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1902403 1045743 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Impact of age on T cell signaling: A general defect or specific alterations?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Impact of age on T cell signaling: A general defect or specific alterations?
چکیده انگلیسی

Decreased immune responsiveness associated with aging is generally termed “immunosenescence”. Several theories have been proposed to explain age-related declines in immune responses. Here, we will focus on and describe potential defects in T cell signal transduction from the membrane to the nucleus, leading to changes in the type, intensity and duration of the response as a major factor contributing to immunosenescence. We will first detail T cell signaling through the T cell receptor (TCR), CD28 and IL-2 receptor (IL-2R) and then discuss the observed age-related alterations to these signaling pathways. The role of membrane rafts in T cell signaling and T cell aging will be described. These factors will be considered in the context of the notion that age-related changes to T cell signaling may be attributed to changes in the functionality of the T cells due to shifts in T cell subpopulations with age. For this reason, we conclude by highlighting the application of multiparametric signaling analysis in leukocyte subsets using flow cytometry as a means to obtain a clearer picture with respect to age-related changes to immune signaling.

Research highlights▶ T cell receptor (TCR) signaling is altered with age. ▶ T cell functions change with age because of altered signaling. ▶ Membrane microdomains (rafts) participate in this phenomenon. ▶ The use of flow cytometry should improve the study of immune cell signaling. ▶ This will enable to discriminate subset specific signaling (naïve/memory/CD28− cells)

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ageing Research Reviews - Volume 10, Issue 3, July 2011, Pages 370–378
نویسندگان
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