کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1902404 1045743 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Influenza vaccine responses in older adults
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Influenza vaccine responses in older adults
چکیده انگلیسی

The most profound consequences of immune senescence with respect to public health are the increased susceptibility to influenza and loss of efficacy of the current split-virus influenza vaccines in older adults, which are otherwise very effective in younger populations. Influenza infection is associated with high rates of complicated illness including pneumonia, heart attacks and strokes in the 65+ population. Changes in both innate and adaptive immune function not only converge in the reduced response to vaccination and protection against influenza, but present significant challenges to new vaccine development. In older adults, the goal of vaccination is more realistically targeted to providing clinical protection against disease rather sterilizing immunity. Correlates of clinical protection may not be measured using standard techniques such as antibody titres to predict vaccine efficacy. Further, antibody responses to vaccination as a correlate of protection may fail to detect important changes in cellular immunity and enhanced vaccine-mediated protection against influenza illness in older people. This article will discuss the impact of influenza in older adults, immunologic targets for improved efficacy of the vaccines, and alternative correlates of clinical protection against influenza that are needed for more effective translation of novel vaccination strategies to improved protection against influenza in older adults.

Research highlights▶ Immune senescence leads to increased susceptibility to influenza and loss of vaccine efficacy. ▶ Age-related changes in innate and adaptive immune function challenge new vaccine development. ▶ Antibody titers as a sole measure of influenza vaccine efficacy may fail to detect enhanced clinical protection. ▶ Novel immunologic targets and correlates of protection are needed to develop effective vaccines.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ageing Research Reviews - Volume 10, Issue 3, July 2011, Pages 379–388
نویسندگان
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