کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1903843 | 1534471 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression of senescence-associated β-galactosidase (SA-β-Gal) by human skin fibroblasts, effect of advanced glycation end-products and fucose or rhamnose-rich polysaccharides
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Expression of senescence-associated β-galactosidase (SA-β-Gal) by human skin fibroblasts, effect of advanced glycation end-products and fucose or rhamnose-rich polysaccharides Expression of senescence-associated β-galactosidase (SA-β-Gal) by human skin fibroblasts, effect of advanced glycation end-products and fucose or rhamnose-rich polysaccharides](/preview/png/1903843.png)
چکیده انگلیسی
Expression by cells of the SA-β-Gal was shown to be a reliable indicator of the switch mechanism used by cells to enter the senescent phenotype. We used this method in order to explore the variation of SA-β-Gal-positive cells with passage number and time spent in culture. Both parameters produced an increase of SA-β-Gal-positive cells. The addition of a Maillard-product (advanced glycation end-product = AGE) to the fibroblast cultures also increased SA-β-Gal expression. Fucose- and rhamnose-rich oligo- and polysaccharides (FROPs and RROPs, respectively) provided a significant protection against this AGE-induced increase of SA-β-Gal-positive cells. It is speculated that these processes might well play an important role in skin aging.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Gerontology and Geriatrics - Volume 48, Issue 2, March–April 2009, Pages 151–154
Journal: Archives of Gerontology and Geriatrics - Volume 48, Issue 2, March–April 2009, Pages 151–154
نویسندگان
V. Ravelojaona, A.M. Robert, L. Robert,