کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1906359 | 1046283 | 2013 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Metabolic changes in the auditory cortex in presbycusis demonstrated by MR spectroscopy Metabolic changes in the auditory cortex in presbycusis demonstrated by MR spectroscopy](/preview/png/1906359.png)
• MRS demonstrated age-related changes of metabolite levels in the human AC.
• Significant decreases of glutamate and N-acetylaspartate was found in the elderly.
• Lactate levels changed significantly according to degree of presbyacusis.
• GABA concentration did not change in the AC of the elderly.
In humans, aging is accompanied by the deterioration of the hearing function — presbycusis. The major etiology for presbycusis is the loss of hair cells in the inner ear; less well known are changes in the central auditory system. Therefore, we used 1 H magnetic resonance spectroscopy at 3 T tomograph to examine metabolite levels in the auditory cortex of three groups of subjects: young healthy subjects less than 30 years old and subjects older than 65 years either with mild presbycusis corresponding to their age or with expressed presbycusis. Hearing function in all subjects was examined by pure tone audiometry (125–16000 Hz). Significant differences were found in the concentrations of glutamate and N-acetylaspartate, with lower levels in aged subjects. Lactate was particularly increased in subjects with expressed presbycusis. Significant differences were not found in other metabolites, including GABA, between young and elderly subjects. The results demonstrate that the age-related changes of the inner ear are accompanied by a decrease in the excitatory neurotransmitter glutamate as well as a lactate increase in the auditory cortex that is more expressed in elderly subjects with large hearing threshold shifts.
Journal: Experimental Gerontology - Volume 48, Issue 8, August 2013, Pages 795–800