کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1907078 1046332 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
C. elegans models of age-associated neurodegenerative diseases: Lessons from transgenic worm models of Alzheimer’s disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
C. elegans models of age-associated neurodegenerative diseases: Lessons from transgenic worm models of Alzheimer’s disease
چکیده انگلیسی

Caenorhabditis elegans has been used to model aspects of a number of age-associated neurodegenerative diseases, including Alzheimer’s, Parkinson’s and Huntington’s diseases. These models have typically involved the transgenic expression of disease-associated human proteins. Here I describe my laboratory’s specific experience engineering C. elegans models of Alzheimer’s disease, and give a general consideration of the advantages and disadvantages of these C. elegans models. The type of insights that might be gained from using these (relatively) simple models are highlighted. In particular, I consider the potential these models have for uncovering common and unique fundamental toxic mechanisms underlying human neurodegenerative diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 41, Issue 10, October 2006, Pages 1007–1013
نویسندگان
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