کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1907118 1534893 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
TOR on the brain
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
TOR on the brain
چکیده انگلیسی

Signaling by target of rapamycin (mTOR in mammals) has been shown to modulate lifespan in several model organisms ranging from yeast to mice. In mice, reduced mTOR signaling by chronic rapamycin treatment leads to life span extension, raising the possibility that rapamycin and its analogs may benefit the aging brain and serve as effective treatments of age-related neurodegenerative diseases. Here, we review mTOR signaling and how neurons utilize mTOR to regulate brain function, including regulation of feeding, synaptic plasticity and memory formation. Additionally, we discuss recent findings that evaluate the mechanisms by which reduced mTOR activity might benefit the aging brain in normal and pathological states. We will focus on recent studies investigating mTOR and Alzheimer's disease, Parkinson's disease, and polyglutamine expansion syndromes such as Huntington's disease.

Research Highlights
► TOR activity modulates life span in several model organisms.
► Reducing TOR activity in mice increases life span.
► Neuronal TOR activity regulates brain function.
► Abnormal TOR activity may contribute to neurodegenerative disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 46, Issues 2–3, February–March 2011, Pages 155–163
نویسندگان
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