کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1907550 1046378 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Testing the rate-of-living/oxidative damage theory of aging in the nematode model Caenorhabditis elegans
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Testing the rate-of-living/oxidative damage theory of aging in the nematode model Caenorhabditis elegans
چکیده انگلیسی

The integration of the rate-of-living and oxidative damage theory of aging predicts that lifespan extension is linked to low energy metabolism, low ROS production rates, low molecular damage and a slow aging rate. In the long-lived Caenorhabditis elegans Ins/IGF-1 mutant daf-2(e1370), low carbonylation levels and postponed morphological decline comply with the latter two of these predictions. However, metabolic rates in daf-2(e1370) refute the rate-of-living theory. The apparent contradiction between increased ROS generation and long lifespan in daf-2(e1370) is reconciled by an enhanced stress defense, acknowledging oxidative damage as a probable cause of aging.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 42, Issue 9, September 2007, Pages 845–851
نویسندگان
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