کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1907551 1046378 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oxidative stress modulation and T cell activation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Oxidative stress modulation and T cell activation
چکیده انگلیسی

During the immune response T cell function is influenced by extrinsic factors, some of which lead to increased protein and DNA damage and are thought to play a role in age-related immune dysfunction. Damage is in part due to reactive oxygen species produced as a result of aerobic metabolism during a vigorous immune response, but in the in vitro models commonly used to study human immunity may also be due to culturing cells under hyperoxic conditions, i.e., in air. Reactive oxygen species (ROS) are ubiquitously generated but an imbalance between ROS production and protection against ROS may severely affect T cell activation. Controlling and modulating oxidative stress in the extracellular milieu may influence T cell signalling and activation. Here, we discuss the relevance of oxidative stress modulation to prevent T cell dysfunction. We draw attention to some technical, but critical, aspects of T cell culture under hyperoxic conditions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 42, Issue 9, September 2007, Pages 852–858
نویسندگان
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