کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1912599 1047182 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The influence of age on the outcome of treatment of elderly patients with colorectal cancer
ترجمه فارسی عنوان
تاثیر سن بر نتیجه درمان بیماران سالمند مبتلا به سرطان کولورکتال
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی

ObjectivesWe investigated factors associated with post-operative mortality rates in those aged ≥ 60, and in particular, the relative survival of age bands within this group.MethodsSecondary analysis of a large comprehensive cohort of the elderly treated for colorectal cancer in the North of England during 1998–2003. We investigated seven risk factors associated with 30-day and 6-month post-operative mortality from colorectal surgery.Results6083 patients aged ≥ 60 underwent colorectal cancer surgery. Approximately 8% had died within 30 days of surgery and 17% had died within 6 months. Thirty-day mortality was greater in the elderly (80 years +) compared to the young-old (60–69 years) (adjusted OR: 3.2, 95% CI 2.4 to 4.4). There was neither a significant difference between the proportions offered curative resections across the age-groups, nor was there a significant association between intent of surgery and 30-day mortality. Six-month mortality rose with age, but the association was stronger in those having curative surgery (adjusted OR: 3.8, 95% CI 2.8 to 5.2) than palliative surgery (adjusted OR: 1.5, 95% CI 1.1 to 2.1). Mortality from emergency surgery at 6-months was particularly high in elderly females.ConclusionsThis large population study adds more weight to the findings that age itself is a major risk factor in the outcome of colorectal surgery in elderly and that 30-day mortality underestimates the longer-term outcome in this age group. There was no significant association between radical resections and 30-day mortality in elderly patients compared to the younger age groups; however, a disproportionately higher mortality at 6 months was seen in elderly female patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Geriatric Oncology - Volume 5, Issue 2, April 2014, Pages 133–140
نویسندگان
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