کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1912938 1047199 2010 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comorbidity and polypharmacy in elderly cancer patients: The significance on treatment outcome and tolerance
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Comorbidity and polypharmacy in elderly cancer patients: The significance on treatment outcome and tolerance
چکیده انگلیسی

Older adults have an increased burden of comorbidity which increases their risk of being exposed to polypharmacy. Because of underrepresentation of elderly cancer patients in clinical trials, knowledge of the influence of comorbidity and polypharmacy on these patients' response and tolerance to antineoplastic treatment is sparse. We reviewed the literature on comorbidity and polypharmacy in elderly cancer patients and the impact of these factors on treatment outcome. Large population-based studies all found an association between comorbidity and survival among elderly cancer patients. However, we need to focus on cancer-specific survival to conclude on the influence of comorbidity on cancer disease and its treatment. Prospective studies are needed to conclude on the influence of comorbidity and polypharmacy on treatment tolerance and response to antineoplastic treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Geriatric Oncology - Volume 1, Issue 2, October 2010, Pages 87–102
نویسندگان
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