Clinical characteristics of Parkinson's disease patients in Greece: A multicenter, nation-wide, cross-sectional study

• 986 Parkinson's disease patients were recruited from 17 centers around Greece.
• Low rates of smoking and alcoholism were observed.
• High age at PD diagnosis independently increased the risk for dementia.
• Positive family history for PD was associated with higher risk for depression.
• None malignant melanoma case and low rates of breast cancer were observed.

Parkinson's disease is a neurodegenerative disease, with a constantly increasing prevalence and a high global financial impact arising from direct and indirect costs. Large-scale, observational studies provide data that support the better comprehension of disease aspects, constitute a baseline reference for future studies and assist comparisons among different patient populations, allowing the recognition of distinctive characteristics and special needs. The present study is the first to depict the clinical characteristics and their interplay in a large sample of Parkinson's disease (PD) patients in Greece. Nine hundred eighty six consecutive PD outpatients were recruited from 17 centers around Greece in the time period from 8/2007 to 7/2009 and were examined and interviewed by movement disorders experts. Multiple clinical characteristics were recorded including age at diagnosis, disease severity, patients' self classification of PD symptoms and their relevance to physician's global clinical impression, smoking, alcohol consumption, presence of family history for PD, dementia, depression, hypertension, cancer and other comorbidities. Associations of high clinical significance were found between certain clinical characteristics.