کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1914103 1535149 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cerebral oxygen metabolism in patients with early Parkinson's disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Cerebral oxygen metabolism in patients with early Parkinson's disease
چکیده انگلیسی

AimDecreased activity of the mitochondrial electron transport chain (ETC) has been implicated in the pathogenesis of Parkinson's disease (PD). This model would most likely predict a decrease in the rate of cerebral oxygen consumption (CMRO2). To test this hypothesis, we compared CMRO2 and cerebral blood flow (CBF) PET scans from PD patients and healthy controls.Materials and methodsNine early-stage PD patients and 15 healthy age-matched controls underwent PET scans for quantitative mapping of CMRO2 and CBF. Between-group differences were evaluated for absolute data and intensity-normalized values.ResultsNo group differences were detected in regional magnitudes of CMRO2 or CBF. Upon normalization using the reference cluster method, significant relative CMRO2 decreases were evident in widespread prefrontal, parieto-occipital, and lateral temporal regions. Sensory-motor and subcortical regions, brainstem, and the cerebellum were spared. A similar pattern was evident in normalized CBF data, as described previously.ConclusionWhile the data did not reveal substantially altered absolute CMRO2 in brain of PD patients, employing data-driven intensity normalization revealed widespread relative CMRO2 decreases in cerebral cortex. The detected pattern was very similar to that reported in earlier CBF and CMRglc studies of PD, and in the CBF images from the same subjects. Thus, the present results are consistent with the occurrence of parallel declines in CMRO2, CBF, and CMRglc in spatially contiguous cortical regions in early PD, and support the hypothesis that ETC dysfunction could be a primary pathogenic mechanism in early PD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 313, Issues 1–2, 15 February 2012, Pages 123–128
نویسندگان
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