کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1915420 1535186 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Disparate cardio-cerebral vascular modulation during standing in multiple system atrophy and Parkinson disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Disparate cardio-cerebral vascular modulation during standing in multiple system atrophy and Parkinson disease
چکیده انگلیسی

PurposeThe dynamic variance of cerebral blood flow velocity (CBFV), monitored by transcranial doppler (TCD), can reveal the integrated effects of cardio-cerebral vascular autoregulation. We investigated the characteristics of CBFV curve during active standing in multiple system atrophy (MSA), Parkinson's disease (PD) and healthy volunteers.MethodsThe CBFV curve of middle cerebral arteries was recorded using TCD in 22 patients with probable MSA; 20 PD patients and 20 volunteers matched for age. All individuals started in a supine posture, followed by abrupt standing for 2 min before returning to supine. The features of CBFV curve were compared among the groups.ResultsIn the healthy volunteers, the CBFV decreased following standing up but quickly rebounded and reached the same or greater level as the supine baseline. Afterwards, the CBFV decreased abruptly to a sustained level, lower than the supine baseline, forming a spike wave that appeared in CBFV curve. This spike wave was present in 5/22 of MSA, significantly less than PD patients (18/20) and volunteers (20/20) (P < 0.001). The CBFV decrease after standing showed no significant difference between MSA than PD (9 ± 7 vs. 6 ± 3 cm/s, P = 0.163).ConclusionsThe different pattern of CBFV curves during active standing suggests MSA may possess cardio-cerebral vascular modulation different from PD. The clinical value of the CBFV curve in differentiating MSA from PD needs further investigation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 276, Issues 1–2, 15 January 2009, Pages 84–87
نویسندگان
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