کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1915829 | 1535195 | 2008 | 4 صفحه PDF | دانلود رایگان |
To investigate whether mitochondrial oxidative damage contributes to the pathogenesis of sporadic amyotrophic lateral sclerosis (sALS), we used high-performance liquid chromatography with an electrochemical detector to measure the concentrations of the reduced and oxidized forms of coenzyme Q10 (CoQ10) in the cerebrospinal fluid (CSF) of 30 patients with sALS and 17 age-matched controls with no neurological diseases.The percentage of oxidized CoQ10 in the CSF of sALS patients were significantly greater than those in the CSF of controls (P < 0.002) and were negatively correlated with duration of illness (ρ = − 0.64, P < 0.001).These results suggest that mitochondrial oxidative damage contributes to the pathogenesis of sporadic amyotrophic lateral sclerosis.
Journal: Journal of the Neurological Sciences - Volume 267, Issues 1–2, 15 April 2008, Pages 66–69