کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1916888 1535219 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Over-expression of p73β results in apoptotic death of post-mitotic hNT neurons
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Over-expression of p73β results in apoptotic death of post-mitotic hNT neurons
چکیده انگلیسی

The p53-related p73 protein is an important mediator of apoptosis, development and tumorigenesis. Previously, we showed that over-expression of the p73β isoform induced apoptosis in proliferating neuronal cells; however, the study did not address the effect of p73 in post-mitotic neurons. To address this question, we used post-mitotic hNT neurons, which have been used as a model of human central nervous system neurons. We found that over-expression of p73β in hNT neurons resulted in apoptosis and an increase in the expression of p57Kip2 and Bax, but no increase in p53 expression. These results suggest that apoptosis of post-mitotic neurons induced by p73β may involve these mediators. Understanding the regulation of p73 expression will be important for understanding the development of the nervous system and may have implications for the treatment of neurological diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 240, Issues 1–2, 15 January 2006, Pages 1–6
نویسندگان
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