کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1917138 | 1047880 | 2015 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Selective estrogen receptor modulators (SERMs): A review of clinical data Selective estrogen receptor modulators (SERMs): A review of clinical data](/preview/png/1917138.png)
SERMs represent a diverse group of molecules with varying levels of estrogenic agonist and antagonist activity in target tissues. SERMs have a long regulatory approval history and have been studied for a variety of therapeutic indications. The clinical effects of SERMs have been evaluated in a large number of phase 3 clinical trials. Many of the available SERMs have proved to be effective as chemo-preventive agents and treatments for breast cancer and a number are useful for the prevention and treatment of osteoporosis. The endometrial effect of SERMs has been a key differentiator in clinical practice and a major hurdle for regulatory approval. The effect of SERMs in the vagina also represents a major distinction among different SERMs. This review summarized key clinical finding of SERMs in different target tissues.
Journal: Maturitas - Volume 80, Issue 1, January 2015, Pages 52–57