کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1917477 1047905 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The quantification of vitamin D receptors in coronary arteries and their association with atherosclerosis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
The quantification of vitamin D receptors in coronary arteries and their association with atherosclerosis
چکیده انگلیسی

ObjectiveThe activated vitamin D receptor (VDR) may have an important role in vascular health. The objective of this study was to determine whether there is an association between the expression of VDRs in coronary arteries and the extent of diet-induced atherosclerosis.MethodsUtilizing a cohort of 39 postmenopausal female cynomolgus monkeys with varying stages of atherosclerosis, histologic sections of the left anterior descending artery (LAD) were analyzed for plaque cross-sectional area, plaque thickness, and VDR quantity using immunohistochemical H-score analysis. The quantities of VDRs were analyzed as a continuous variable and were divided at the median intimal H-score into high vs. low groupings.ResultsIn the LAD, a significant negative correlation was observed between the quantity of VDR and plaque size (both cross-sectional area [p < 0.001] and plaque thickness [p < 0.001]). Monkeys in the low VDR group had a significantly greater cross-sectional plaque area (1.2 mm2) and greater plaque thickness (0.3 mm) than those in the high VDR group (0.4 mm2, p = 0.005; 0.1 mm, p = 0.003, respectively).ConclusionsLower concentrations of VDRs in a main coronary artery were associated with greater atherosclerotic plaque size in postmenopausal female monkeys. Given that coronary artery atherosclerosis is a major cause of coronary heart disease in postmenopausal women, further research to ascertain the relationship between VDRs and atherosclerosis is warranted.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Maturitas - Volume 73, Issue 2, October 2012, Pages 143–147
نویسندگان
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