کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1918163 1047942 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Exercise training associated with estrogen therapy induced cardiovascular benefits after ovarian hormones deprivation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Exercise training associated with estrogen therapy induced cardiovascular benefits after ovarian hormones deprivation
چکیده انگلیسی

Menopause is recognized as a period of increased risk for coronary heart disease. Although the benefits of exercise training in lowering cardiovascular risk factors are well established, the risks and benefits of hormone therapy have been questioned. The purpose of the present study was to investigate the effects of estrogen therapy (HT) associated or not with exercise training (ET) in autonomic cardiovascular control in ovariectomized (OVX) rats. Female rats were divided into: control, OVX, OVX + HT, OVX + ET and OVX + HT + ET. HT was performed using a 0.25 mg 8-weeks sustained release pellet. Trained groups were submitted to an 8-week exercise training protocol on treadmill. Baroreflex sensitivity (BRS) was evaluated by heart rate responses to arterial pressure (AP) changes, and vagal and sympathetic tonus by pharmacological blockade. Ovariectomy induced an AP increase (123 ± 2 mmHg vs. 108 ± 2 mmHg), BRS impairment (∼69%), sympathetic activation (∼100%) and vagal tonus reduction (∼77%) compared to controls. HT or ET normalized the changes in parasympathetic tonus. However, only the association HT + ET was able to promote normalization of AP, BRS and sympathetic tonus, as compared to controls. These results indicate that ET induces cardiovascular and autonomic benefits in OVX rats under HT, suggesting a positive role of this association in the management of cardiovascular risk factor in postmenopausal women.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Maturitas - Volume 65, Issue 3, March 2010, Pages 267–271
نویسندگان
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