کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1918546 1047959 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Polymorphic variants of genes encoding MTHFR, MTR, and MTHFD1 and the risk of depression in postmenopausal women in Poland
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Polymorphic variants of genes encoding MTHFR, MTR, and MTHFD1 and the risk of depression in postmenopausal women in Poland
چکیده انگلیسی

ObjectiveDisturbances in the folate-dependent one-carbon metabolism have been reported in depression. Polymorphic variants of genes encoding key enzymes of folate and methionine metabolism may have an impact on catecholamine catabolism conducted by catechol-O-methyltransferase.MethodsThe distribution of polymorphisms of genes encoding methylenetetrahydrofolate reductase (MTHFR); methionine synthase (MTR); 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase (MTHFD1) was examined in postmenopausal women with (n = 83) and without depression (n = 89).ResultsWe found a significant contribution of the MTHFR 677C > T polymorphic variants to depression in postmenopausal women. Odds ratio (OR) for women with depression and MTHFR TT genotype was 3.478 (95% CI = 1.377–8.783), P = 0.0096 and OR of the TT and CT genotypes was 2.345 (95% CI = 1.258–4.373), P = 0.0086. Moreover, after stratification based on depression severity in postmenopausal women, we found that the MTHFR TT genotype displayed a 4.831-fold increased risk of moderate and severe depression (95% CI = 1.975–11.820, P = 0.0008). We did not observe statistical differences in the distribution of MTR 2756A > G and MTHFD1 1958G > A polymorphic variants in groups of postmenopausal women with and without depression. However, the MTR GG genotype exhibited a 5.750-fold increased risk of moderate and severe depression in postmenopausal women (95% CI = 1.547–21.379, P = 0.013).ConclusionsOur findings indicate a significant role of folate and possible methionine metabolism involvement in the development of depression in postmenopausal women.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Maturitas - Volume 61, Issue 3, 20 November 2008, Pages 252–255
نویسندگان
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