کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1918744 | 1047972 | 2007 | 4 صفحه PDF | دانلود رایگان |
Steroids arriving from the gonads via the circulation modulate brain function, affecting gender differentiation and sexually differentiated behavioral responses, but also the ability of the brain to process, store and retrieve sensory information. Androgens play a pivotal neuroactive role during the “organizational/developmental” phase, mainly in the fetal–neonatal period, when participated to the formation of neuronal circuits, as well as during the aging process when it has been demonstrated to directly affect hippocampal spine synapse density, suggesting a physiopathological role for androgen in the modulation cognitive function and development of neurodegenerative disease. The present short review will focus on the neuroactive effect of androgen with particular regard to the Δ4 and Δ5 androgen replacement therapy.
Journal: Maturitas - Volume 57, Issue 1, 20 May 2007, Pages 27–30